Nimesulide

DB04743ApprovedInvestigationalWithdrawnSmall molecule

Nimesulide is a cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Chemical structure of Nimesulide
Mechanism
Curator reviewed
Primary indication
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.Curator reviewed · 4 structured indications
Formula / weight
C13H12N2O5S · 308.31 g/mol (avg)
Code names
R-805

Resolves to

Compound
UNIIV4TKW1454MCAS51803-78-2ChEMBLCHEMBL56367ChEBI44445PubChem4495KEGGD01049
Clinical / RWD
RxNorm53694ATCM01AX17ATCM02AA26PharmGKBPA137179528
Structure
InChIKeyHYWYRSMBCFDLJT-UHFFFAOYSA-NSMILESCS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O
Targets
P35354PTGS2P02788LTFP50591TNFSF10Q9NZK7PLA2G2E

What you can answer from here — as of September 21, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2,020Drug interactionsStructured to mechanism, not free text
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12Clinical trialsPhase, status and sponsor resolved per trial
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4Structured indicationsCondition, population, route and combination as fields, not prose
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21ContraindicationsEach with its own population and attribute set
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328Marketed productsAcross 4 countries and 116 labellers
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2ATC codesIncluding every combination product, plus 30 drug categories
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11+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Nimesulide, and which of those have an active Phase 3 trial?

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